New study reverses Alzheimer’s in mice, while similar big clinical trial fails

Another major pharma player, Roche, canceled its BACE1 research back in 2013, but several large-scale trials for BACE1 inhibitors are still currently in development or underway. The Merck Phase 3 trial failure does strike a giant blow to this once-promising field, despite this new research reiterating the pathway as effective, at least in animal models.

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